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Protein Kinase C Delta Overexpressing Transgenic Mice Are Resistant to Chemically but Not to UV Radiation-Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2

January 2006 in “ Cancer Research ”

Moammir Hasan Aziz, Deric L. Wheeler, Bhushan Bhamb, Ajit Kumar Verma

Protein Kinase C δ PKCδ squamous cell carcinoma SCC cytokines cyclooxygenase-2 COX-2 apoptosis UV radiation chemical carcinogens

TLDR Mice with extra PKCδ resist chemical-induced skin cancer but not UV-induced.

The study examined the role of Protein Kinase C δ (PKCδ) in squamous cell carcinoma (SCC) development using transgenic mice overexpressing PKCδ. These mice were resistant to SCCs induced by chemical carcinogens but not to those caused by UV radiation, suggesting a protective mechanism against chemical carcinogenesis. This resistance was linked to enhanced apoptosis and suppression of cytokines and COX-2 expression in response to chemical exposure, but not UV radiation. The findings highlighted different molecular mechanisms in SCC development via chemical and UV exposure, emphasizing the complexity of cancer resistance and potential pathways for targeted prevention.

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research Protein Kinase C Epsilon Signals Ultraviolet Light-Induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism

28 citations , January 2005 in “Photochemistry and Photobiology”

Protein kinase C epsilon may increase skin cancer risk by affecting nearby cells.

research Protein Kinase C Epsilon Is Linked to 12-O-Tetradecanoylphorbol-13-Acetate-Induced Tumor Necrosis Factor-Alpha Ectodomain Shedding and the Development of Metastatic Squamous Cell Carcinoma in Protein Kinase C Epsilon Transgenic Mice.

79 citations , October 2003 in “PubMed”

Overexpression of PKCepsilon leads to increased TNFalpha, promoting metastatic squamous cell carcinoma in mice.

research Activation of Cutaneous Protein Kinase Cα Induces Keratinocyte Apoptosis and Intraepidermal Inflammation by Independent Signaling Pathways

74 citations , September 2003 in “The Journal of Immunology”

Activating PKCα in skin causes cell death and inflammation through different pathways.

research Cyclooxygenase-2 Overexpression in the Skin of Transgenic Mice Results in Suppression of Tumor Development

113 citations , May 2002 in “PubMed”

Overexpressing COX-2 in mice skin reduces skin tumor development.

research Transgenic Mice Overexpressing Protein Kinase C Epsilon in Their Epidermis Exhibit Reduced Papilloma Burden but Enhanced Carcinoma Formation After Tumor Promotion

99 citations , February 2000 in “PubMed”

Overexpressing PKCepsilon in mice reduces papillomas but increases carcinomas.

research Overexpression of Protein Kinase C-α in the Epidermis of Transgenic Mice Results in Striking Alterations in Phorbol Ester-Induced Inflammation and COX-2, MIP-2, and TNF-α Expression but Not Tumor Promotion

135 citations , October 1999 in “Journal of Cell Science”

Overexpressing PKCα in mice skin increases inflammation but doesn't affect tumor growth.