Pyruvate Kinase M2 Role in Cardiovascular Repair

Pyruvate Kinase M2 (PKM2) is highlighted as a promising therapeutic target for cardiac repair due to its roles in enhancing cardiomyocyte (CM) proliferation, reducing oxidative stress, and aiding tissue regeneration. PKM2 achieves these effects by modulating metabolic pathways, such as directing glycolytic flux towards the pentose phosphate pathway, which increases NADPH production and decreases reactive oxygen species. Studies demonstrate that PKM2 overexpression via modRNA delivery improves cardiac function and reduces scar size after myocardial infarction. PKM2 interacts with proteins like beta-catenin and CHK1, further supporting cardiac repair. While RNA-based therapies offer advantages, challenges such as delivery methods and potential risks need to be addressed, necessitating further research to confirm PKM2's safety and efficacy in clinical settings.