PLA2R1 Overexpression Causes Podocyte Injury by Inhibiting the Cell Cycle: A Clinical Cross-Sectional Investigation and Cellular Study

    June 2025 in “ International Journal of Nephrology and Renovascular Disease ”
    Wei Liang, Hua Zhang, Yi Wu, Zhi‐Wei Lai, Weiqiang Zhang, Yuhao Cao, Lishan Tan, Zibo Xiong, Guang Yang, Zuying Xiong
    TLDR PLA2R1 overexpression harms kidney cells by stopping their growth cycle.
    The study investigates the effects of PLA2R1 overexpression on podocyte injury, revealing that it inhibits the podocyte cell cycle, which may contribute to the pathogenesis of primary membranous nephropathy (PMN). The findings suggest that PLA2R1-related PMN could involve an additional immune response, providing new insights that could aid in the development of treatments for PMN.
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