Plant-derived extracellular vesicles delivered by microinfusion microneedling for androgenetic alopecia: a retrospective case series

This retrospective case series investigated the use of plant-derived extracellular vesicles (EVs) delivered via microinfusion microneedling (MMP®) for treating androgenetic alopecia (AGA) in 20 adults. Patients underwent six monthly sessions, and the treatment was well tolerated, with 85% reporting no adverse effects. Subjectively, 95% of patients perceived improvement, with 55% noting marked improvement. Blinded evaluations indicated mild-to-marked improvement in 70% of cases clinically, and 50% trichoscopically, with 45% showing stabilization-to-mild improvement. The study concludes that plant-derived EVs delivered by MMP® are feasible, well tolerated, and show promising efficacy for AGA treatment.