Large-Scale Plasma Proteomics and Genetic Integration Uncover Novel Biological Pathways in Male Pattern Baldness

    Lingfeng Pan, Caihong Li, Philipp Moog, Samuel Knoedler, Haydar Kükrek, Ulf Dornseifer, Hans-Günther Machens, Jun Jiang
    TLDR New biological pathways and potential treatment targets for male pattern baldness were identified.
    This study, involving 24,069 men from the UK Biobank, integrates large-scale plasma proteomics and genetic data to uncover novel biological pathways in male pattern baldness (MPB). It identifies 47 proteins associated with MPB severity and prioritizes five candidate genes: CD38, FGF5, TACSTD2, DPEP1, and PLB1. CD38 is highlighted as a druggable target due to its role in NAD+ depletion and follicular senescence, suggesting potential therapeutic strategies beyond androgen signaling. The study emphasizes the complexity of MPB, linking it to pathways related to epidermis development, hair cycle regulation, and cell adhesion, and proposes non-hormonal therapeutic interventions. Validation in human scalp tissue supports the causal role of these genes in MPB.
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