TLDR Combining platelet concentrates with stem cells improves regenerative therapies.
This article reviews the factors affecting the efficacy of mesenchymal stem cells (MSCs) transplantation when combined with platelet concentrates (PCs), focusing on donor characteristics, application methods, and environmental influences. It explores strategies for optimizing MSCs transplantation, including preconditioning and combined therapies, and examines the signaling pathways and proteomic characteristics involved. The review highlights the effectiveness of combined therapies and discusses advancements in biomaterials for regenerative medicine, aiming to enhance understanding and provide guidance for research and clinical practice.
November 2023 in “Periodontology 2000” Injectable platelet-rich fibrin has improved healing and regeneration in various medical fields and can be more effective than previous treatments.
24 citations
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November 2023 in “International Journal of Molecular Sciences” PRP and ADSC therapies show promise in improving symptoms of genital lichen sclerosus with minimal side effects.
16 citations
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August 2023 in “Tissue Engineering and Regenerative Medicine” 
1 citations
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August 2023 in “International Journal of Molecular Sciences” Platelet Rich Plasma-Derived Extracellular Vesicles show promise for healing and regeneration but need standardized methods for consistent results.
24 citations
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August 2023 in “International Journal of Molecular Sciences” Platelet-rich fibrin shows promise in healing cartilage and joint injuries but needs more testing.
June 2023 in “Journal of Burn Care & Research” Using both bone marrow concentrate and platelet-rich plasma together improves skin wound healing in mice.
39 citations
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July 2021 in “Stem Cell Research & Therapy” Using fat stem cells and blood cell-rich plasma together improves healing in diabetic wounds by affecting cell signaling.
6 citations
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January 2021 in “TURKISH JOURNAL OF MEDICAL SCIENCES” 
23 citations
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September 2020 in “Journal of Cosmetic Dermatology” Injectable Platelet-Rich Fibrin (I-PRF) showed positive results for treating hair loss, skin texture, wrinkles, and wounds.
