Platelet-Rich Fibrin Matrix

Platelet-rich plasma (PRP) was initially developed to treat thrombocytopenia but later found applications in various medical fields, including dermatology, for wound healing, hair restoration, and skin rejuvenation. Despite its effectiveness, PRP's short-lived growth factor release and poor mechanical properties led to the development of a second-generation platelet-rich fibrin matrix (PRFM). PRFM aimed to address these limitations, offering improved tissue regeneration capabilities. However, PRP faced criticism due to the lack of standardized guidelines and protocols, which affected its consistent application and outcomes.