The Spectrum of PLEC Sequence Variants and Related Plectinopathies Including Novel Association with Epidermolysis Bullosa Pruriginosa

November 2022 in “ Journal of Investigative Dermatology ”

Hassan Vahidnezhad, L. Youssefian, A. Tavasoli, N. Harvey, Homeyra Mahmoudi, E. Kalamati, A. Varghaei, F. Vahidnezhad, A. Saeidian, J. Uitto

cutaneous injury neutrophil recruitment zebrafish Tg(lyz:DsRed2)nz50 transgenic casper mutant BODIPY lyz:dsRed neutrophils skin injury neutrophil response fish model fluorescent dye

TLDR Neutrophils quickly respond to skin injury.

The document discusses a study on neutrophil recruitment after cutaneous injury in zebrafish. The researchers used a Tg(lyz:DsRed2)nz50 transgenic casper mutant zebrafish with skin stained in BODIPY and neutrophils in orange (lyz:dsRed) to observe the response 0.5 – 17.25 hours post injury. The study found a mass influx of neutrophils during this time, indicating that neutrophils respond quickly to cutaneous injury. The research was conducted by Leah Greenspan PhD, Keith Ameyaw, Daniel Castranova, Caleb Mertus, and Brant Weinstein PhD from the Division of Developmental Biology, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health.

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