Polygenic Risk Score Predicting Susceptibility and Outcome of Benign Prostatic Hyperplasia in the Han Chinese

May 2024 in “ Human Genomics ”

Sheng-Chun Hung, Li‐Wen Chang, Tzu‐Hung Hsiao, Guan‐Cheng Lin, Shian‐Shiang Wang, Jian‐Ri Li, I‐Chieh Chen

This study, involving 12,474 Han Chinese men, demonstrates that polygenic risk scores (PRS) can effectively predict the risk and outcomes of benign prostatic hyperplasia (BPH). Individuals in the highest PRS quartile showed a significantly higher risk of developing BPH, larger prostate volumes, and a poorer response to 5-alpha-reductase inhibitor (5ARI) treatment compared to those in the lowest quartile. Additionally, they had a higher likelihood of undergoing transurethral resection of the prostate (TURP). The study suggests that PRS could be a valuable tool for predicting BPH risk and treatment outcomes, although further large-scale studies are needed for validation.

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