Polymer and Lipid-Based Nanostructures for Wound Healing with Barrier-Resolved Design

This review discusses the use of polymer- and lipid-based nanostructures for improving wound healing by addressing issues such as microbial contamination and inflammation. It highlights the importance of designing these nanostructures with effective diameters of 50-300 nm to perform well in protease- and salt-rich environments. The review emphasizes the need for contamination control on the first day, support for cell proliferation by day three, and sustained tissue remodeling beyond one week. Key findings include the role of interfacial charge and protein corona in nanostructure uptake, the benefits of lipid bilayers for dual loading, and the advantages of degradable polymer matrices for sustained release. Hybrid constructs are noted for reducing early burst release and enhancing storage stability.