Polyomavirus Associated Trichodysplasia Spinulosa in a Pediatric Kidney Transplant Recipient

    July 2025 in “ Pediatric Transplantation
    Nivedita Pande, Philippe Leblanc, Barbara Miedzybrodzki, Myriam Carlos, Chelsea Maedler‐Kron, Christos Karatzios, Marie‐Michèle Gaudreault‐Tremblay, Mallory L. Downie
    TLDR A rare skin infection in a 10-year-old kidney transplant patient was successfully managed by adjusting medication.
    This document reports a case of trichodysplasia spinulosa (TS), a rare skin infection caused by a polyomavirus, in a 10-year-old girl who had a kidney transplant. The condition, which can be mistaken for other skin issues, was confirmed through a skin biopsy. Treatment involved reducing immunosuppression and administering leflunomide and valganciclovir, leading to successful management of TS without graft rejection. The case underscores the rarity of TS in pediatric transplant recipients and the challenges in treatment, noting that the specific role of valganciclovir remains unclear.
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