Exploring the Role of Two Polypeptide Nanofiber Gels Derived from RADA16-I Self-Assembly in Accelerating Burn Wound Healing

This study investigates the effects of peptide nanofiber gels RG and RJ, derived from RADA16-I self-assembly, on healing deep second-degree burn wounds. The gels, enhanced with GLP-1 analog or Jagged-1 protein, exhibit improved mechanical properties and promote cell proliferation and migration. In vivo, RG and RJ significantly accelerated wound healing, achieving closure rates of 89.5% and 76.8% after 14 days, compared to 70.1% for R and 67% for the control. The enhanced healing is due to increased angiogenesis, reduced inflammation, and better tissue regeneration, suggesting RG and RJ as promising treatments for burn wounds.