TLDR Minoxidil can be effectively encapsulated in coated nanovesicles for potential drug delivery.
This study investigated the encapsulation of minoxidil in polystyrene-b-poly(acrylic acid) (PS-b-PAA) nanovesicles coated with chemically modified chitosans. The nanovesicles, produced using an organic cosolvent method, had diameters under 150 nm and a negative zeta potential, which changed to positive after coating. The encapsulation efficiency of minoxidil was approximately 50%, indicating potential as drug delivery carriers. The study confirmed the successful coating and stabilization of nanovesicles through dynamic light scattering (DLS), zeta potential measurements, and transmission electron microscopy (TEM). The removal of residual organic solvent was more effective with dialysis than evaporation. Future research will focus on further characterization and testing of these systems.
77 citations
,
January 2015 in “International Journal of Biological Macromolecules” Chitosan nanoparticles improve minoxidil delivery to hair follicles for better alopecia treatment.
52 citations
,
November 2013 in “European Journal of Pharmaceutical Sciences” Chitosan-decorated polymersomes improve finasteride delivery for hair loss treatment.
25 citations
,
January 2010 in “International Journal of Pharmaceutics” Particle properties affect drug retention and release in minoxidil foams, with lipid nanoparticles having higher loading capacity.
128 citations
,
July 2009 in “International Journal of Pharmaceutics” PEVs improve minoxidil skin penetration, increasing hair growth.
181 citations
,
July 2004 in “Journal of controlled release” Smaller nanoparticles improve minoxidil absorption through hair follicles.
74 citations
,
May 2004 in “Journal of Clinical Hypertension” Minoxidil effectively treats severe hypertension, but watch for side effects.
16 citations
,
September 2018 in “Journal of Molecular Liquids” The PS-b-PAA copolymer nanomicelles are effective for delivering a cancer treatment drug in photodynamic therapy.
21 citations
,
April 2021 in “ACS omega” Curcumin can be effectively loaded into polystyrene nanoparticles, which are safe for human cells and more biocompatible with curcumin inside.
52 citations
,
November 2013 in “European Journal of Pharmaceutical Sciences” Chitosan-decorated polymersomes improve finasteride delivery for hair loss treatment.
3 citations
,
January 2022 in “Pharmaceutics” Nanostructured delivery systems could potentially improve hair loss treatment by targeting drugs to hair follicles, reducing side effects and dosage, but the best size, charge, and materials for these systems need further investigation.
48 citations
,
July 2023 in “Biomedicines” Hydrogel-forming microneedles are promising for safe, efficient, and controlled drug delivery through the skin.
