Association Between Postoperative Nadir Hematocrit and Mortality Within 28 Days After Coronary Artery Bypass Grafting: A Retrospective Cohort Study Based on the MIMIC-IV Database
May 2026
in “
Medicine
”
TLDR Lower postoperative hematocrit levels increase the risk of death within 28 days after coronary artery bypass surgery.
This retrospective cohort study analyzed data from 6,020 patients in the MIMIC-IV database to examine the link between postoperative nadir hematocrit (nHCT) levels and 28-day mortality after coronary artery bypass grafting (CABG). The study found that lower nHCT levels were significantly associated with higher mortality rates, with the optimal nHCT range for the lowest mortality risk being 27% to 31%. The study suggests that monitoring and managing nHCT levels could be crucial for improving short-term outcomes in CABG patients, although further prospective studies are needed to confirm these findings and establish causal relationships.