Virilization and Metabolic Disease in Postmenopausal Woman Related to Ovarian Hyperplasia and Hyperthecosis

The document discussed a case of a 51-year-old postmenopausal woman who developed signs of virilization over 12 months, alongside poorly managed type 2 diabetes and hypertension. Laboratory tests revealed elevated serum androgen levels and hyperinsulinemia, while imaging showed enlarged ovaries with normal adrenal glands, suggesting ovarian stromal hyperthecosis. A bilateral laparoscopic anexectomy confirmed the diagnosis, and serum testosterone levels normalized post-surgery. The study highlighted the diagnostic challenge of postmenopausal virilization, emphasizing the importance of detailed clinical history, correct laboratory interpretation, and imaging to differentiate benign from malignant causes and to guide treatment.