Prenatal Exposure to Delta-9-Tetrahydrocannabinol Alters the Expression of miR-122-5p and Its Target IGF1R in the Adult Rat Ovary

    July 2022 in “ International Journal of Molecular Sciences ”
    Annia A. Martínez-Peña, Kendrick Lee, Madison Pereira, Ahmed N. Ayyash, Jim Petrik, Daniel B. Hardy, Alison C. Holloway
    TLDR Prenatal THC exposure may harm ovarian health and fertility.
    The study found that prenatal exposure to delta-9-tetrahydrocannabinol (THC) in rats led to the upregulation of miR-122-5p and decreased expression of its target, insulin-like growth factor 1 receptor (Igf1r), in adult ovaries. This alteration was linked to increased apoptosis and impaired follicular development, suggesting potential long-term impacts on ovarian health, subfertility, or premature reproductive senescence. The research highlighted the potential reproductive risks associated with cannabis use during pregnancy.
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