Prevention of Chemotherapy Drug-Mediated Human Hair Follicle Damage: Combined Use of Cooling with Antioxidant Suppresses Oxidative Stress and Prevents Matrix Keratinocyte Cytotoxicity

    July 2025 in “ Frontiers in Pharmacology
    Khalidah Ibraheem, Adrian L. Smith, Andrew Collett, Nikolaos T. Georgopoulos
    TLDR Cooling with antioxidants helps protect hair during chemotherapy.
    The study demonstrates that cooling, when combined with antioxidants, effectively reduces chemotherapy-induced damage to human hair follicles by preventing cell apoptosis and maintaining hair follicle viability and functionality. This approach compensates for insufficient protection under less-than-ideal cooling conditions and shows promise for enhancing the effectiveness of scalp cooling in preventing chemotherapy-induced alopecia (CIA), thereby potentially improving the quality of life for cancer patients undergoing chemotherapy.
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