Prevention of Male Late-Onset Hypogonadism by Natural Polyphenolic Antioxidants

The document reviews the potential of natural polyphenolic antioxidants, such as flavonoids, resveratrol, and phenolic acids, in preventing male late-onset hypogonadism by enhancing testosterone production. These compounds can boost testosterone by improving steroidogenic enzyme activities and supporting hypothalamus-pituitary gland axis signaling. Flavonoids like luteolin and quercetin, as well as resveratrol, may delay hypogonadism symptoms, offering a natural alternative to testosterone replacement therapy. However, the effects of these antioxidants on testosterone levels are complex and influenced by factors like concentration and species differences. While promising, further research is needed to fully understand their mechanisms and confirm their efficacy in maintaining hormonal balance and preventing hypogonadism in aging men.