The Prevention of Benign Prostatic Hyperplasia (BPH)

    December 2016 in “ Medical Hypotheses ”
    W.G. Roper
    TLDR A vaccine may prevent benign prostatic hyperplasia (BPH).
    The document discussed the development and prevention of benign prostatic hyperplasia (BPH), attributing its cause to repeated colonization and destruction of E. coli in the prostate gland, leading to the release of phospholipase D (PLD) and subsequent production of lysophosphatidic acid (LPA). This process stimulates prostatic smooth muscle growth and affects connective tissue through autocrine and paracrine hormones, with androgens playing a permissive role. The study highlighted the importance of zinc in prostatic fluid, the role of testosterone and dihydrotestosterone (DHT) in prostate development, and the potential involvement of genes and prolactin in BPH. The conclusion emphasized the proven stimulation of LPA by PLD and its dose-related effects on prostatic smooth muscle and connective tissue.
    Discuss this study in the Community →

    Related Community Posts Join

    6 / 144 results
      FCE 28260: A Forgotten 5α-Reductase Inhibitor

      community FCE 28260: A Forgotten 5α-Reductase Inhibitor

      in Research  330 upvotes 1 year ago
      FCE 28260 (PNU 156765), an under-explored 5α-reductase inhibitor, showcases promising results in research by Giudici et al., outperforming well-known treatments like Finasteride in reducing the conversion of testosterone to DHT. Its superior efficacy, demonstrated through lower IC50 values in both natural and human recombinant enzyme studies, suggests it could offer more effective management of DHT-related conditions. Additionally, its lower molecular weight hints at better potential for topical application, potentially offering advantages in treating conditions such as androgenic alopecia. Despite its potential, it has not advanced in development, possibly due to financial limitations, leaving its therapeutic prospects and side effect profile largely unexplored.

      community How is dht not beneficial to you?

      in Finasteride/Dutasteride  109 upvotes 1 week ago
      DHT is important for sexual function and mood, but finasteride and dutasteride can reduce DHT, causing side effects like reduced libido and erectile dysfunction. These treatments are effective for hair loss, but their impact on DHT leads to debate.

      community risks with finasteride and dutasteride

      in Research/Science  140 upvotes 7 months ago
      Finasteride and dutasteride have potential risks, including post-finasteride syndrome, but are commonly used for hair loss. RU58841, minoxidil, and needling are suggested as alternatives, though all treatments carry risks.

      community Wtf have we been doing for the last 30 years

      in Treatment  548 upvotes 1 year ago
      Hair loss treatments like finasteride, minoxidil, and dutasteride work but have side effects. A permanent cure is still not available due to the complexity of hair loss and limited investment.

    Similar Research

    5 / 1000+ results