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August 2019 in “ Stem cells ”

Stuart P. Atkinson

Norrin hair follicle growth alopecia miRNA GPCR Sox9 dermal papilla cells wound healing hair follicle formation engineered skin substitutes hair loss hair growth skin substitutes

TLDR New treatments for hair loss, fertility, and wound healing are being explored.

The document summarized recent research from the journal "STEM CELLS," including a study by le Riche et al. that identified Norrin as a regulator of hair follicle growth, suggesting new treatments for hair loss conditions like alopecia. Other highlighted studies included Guo et al.'s exploration of miRNA-GPCR-Sox9 networks in zebrafish for fertility treatments, Mead and Tomarev's findings on MSC-derived exosomes protecting retinal ganglion cells, and Leirós et al.'s demonstration of dermal papilla cells enhancing wound healing and hair follicle formation in engineered skin substitutes.

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research Extracellular Vesicles from Activated Dermal Fibroblasts Stimulate Hair Follicle Growth Through Dermal Papilla-Secreted Norrin

37 citations , June 2019 in “Stem cells”

Special particles from skin cells can promote hair growth by activating a specific growth signal.

Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

research Exosomes Derived from Human Dermal Papilla Cells Promote Hair Growth in Cultured Human Hair Follicles and Augment the Hair-Inductive Capacity of Cultured Dermal Papilla Spheres

58 citations , March 2019 in “Experimental Dermatology”

Exosomes from human skin cells can stimulate hair growth and could potentially be used for treating hair loss.

research Regulation of Hair Follicle Development by Exosomes Derived from Dermal Papilla Cells

87 citations , April 2018 in “Biochemical and Biophysical Research Communications”

Exosomes from dermal papilla cells can help grow hair and might treat hair loss.

Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

research Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

68 citations , August 2014 in “Stem Cells Translational Medicine”

Dermal papilla cells help wounds heal better and can potentially grow new hair.

research The Hair Follicle as a Dynamic Mini-Organ

759 citations , February 2009 in “Current Biology”

Hair follicles are complex, dynamic mini-organs that help us understand cell growth, death, migration, and differentiation, as well as tissue regeneration and tumor biology.

research Molecular Mechanisms Regulating Hair Follicle Development

854 citations , February 2002 in “The journal of investigative dermatology/Journal of investigative dermatology”

Understanding hair follicle development can help treat hair loss, skin regeneration, and certain skin cancers.