Proangiogenic and Collagen-Promoting Effects of a 70% Ethanol Extract of Grateloupia Angusta in Cutaneous Wound Models

    March 2026 in “ International Journal of Molecular Sciences ”
    Seongtae Jeong, Seahyoung Lee, Bomi Kim, Hanbyeol Moon, Hojin Kim, Myung Hun Yeon, J. S. Choi, SANG WOO KIM, Il-Kwon Kim, Byeong‐Wook Song, Gyoonhee Han, Soyeon Lim
    Image of study
    TLDR Grateloupia angusta extract helps heal wounds faster and improve skin repair.
    The study explores the wound-healing potential of a 70% ethanol extract of Grateloupia angusta (GAE) using in vitro and in vivo models. GAE was found to enhance wound healing by promoting angiogenesis and collagen production. In vitro, it increased VEGF expression and improved viability, migration, and tube formation in endothelial cells, while also boosting collagen synthesis in fibroblasts. In vivo, GAE accelerated wound closure in mice, enhancing granulation and re-epithelialization. Despite the small sample size, these findings suggest GAE's promise as a therapeutic agent for wound healing, warranting further research into its bioactive components and mechanisms.
    Discuss this study in the Community →