Procyanidin Oligomers Selectively and Intensively Promote Proliferation of Mouse Hair Epithelial Cells In Vitro and Activate Hair Follicle Growth In Vivo
TLDR Procyanidin compounds from grape seeds were found to significantly increase mouse hair growth.
In a study from 1999, researchers found that procyanidin oligomers, specifically procyanidin B-2 (a dimer) and procyanidin C-1 (a trimer), derived from grape seeds, significantly promoted the proliferation of mouse hair epithelial cells in vitro and stimulated hair growth in vivo. The procyanidin B-2 showed a maximum growth-promoting activity of about 300% at a concentration of 30 microM, while procyanidin C-1 reached about 220% at 3 microM, compared to control levels set at 100%. These compounds were more effective than other flavonoid compounds tested. The study also demonstrated that only epithelial cells, such as hair keratinocytes, responded to procyanidin oligomers. When applied topically at 1% concentration to C3H mice in the telogen phase of hair growth, procyanidin oligomers significantly induced hair regeneration, with procyanidin B-2 achieving 69.6% ± 21.8%, procyanidin B-3 achieving 80.9% ± 13.0%, and procyanidin C-1 achieving 78.3% ± 7.6% hair regrowth on the shaven area, compared to a 41.7% (SD = 16.3%) regrowth with the vehicle only. This study suggested the potential of procyanidin oligomers as agents to induce hair growth.
100 citations
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November 1996 in “Molecular Medicine Today”
Growth factors and cytokines are important for hair growth and could potentially treat hair loss, but more research is needed to overcome challenges before they can be used in treatments.
Procyanidin B2, a compound derived from Annurca apples, as a potential treatment for pattern hair loss. Several clinical studies were mentioned, which found that procyanidin B2 could increase hair growth, density, and keratin content. Other treatments such as Minoxidil, Finasteride, and RU58841 were not discussed.
The conversation discusses hair loss and specific treatments like Minoxidil, Finasteride, and RU58841. It also highlights ProcyanidinB-2 as a secret ingredient for hair growth.
Personal experience with Procyanidin B2 shows it's ineffective for hair loss. Viviscal Pro supplement tablets, containing Procyanidin B2, didn't help after 8 months of use.
Hair loss discussion includes treatments like Minoxidil, finasteride, and RU58841. Conversation focuses on foods with sufficient procyanidin b2, such as dark chocolate and apples, and the required dosage.
Hair loss discussion includes homemade 15% Procyanidin B2 apple skin extract as alternative to Minoxidil. User reports thicker hair, but no new growth yet.
User discusses a promising topical Procyanidin B2 treatment for hair loss. Users share mixed experiences and mention effective treatments like finasteride, minoxidil, and LLLT.
21 citations
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May 2022 in “Frontiers in Cell and Developmental Biology”
Hair growth and health are influenced by factors like age, environment, and nutrition, and are controlled by various molecular pathways. Red light can promote hair growth, and understanding these processes can help treat hair-related diseases.
