Progesterone Regulates Corticosterone Elevation and Alterations in Spatial Memory and Exploratory Behavior Induced by Stress in Wistar Rats

June 2010 in “ Universitas Psychologica ”

Yolanda Díaz-Burke, C E Valencia-Alfonso, Claudia Elena González-Sandoval, Miguel Huerta, Xóchitl Trujillo, Lourdes Diaz, Joaquı́n Garcı́a‐Estrada, Sonia Luquín

progesterone corticosterone spatial memory exploratory behavior chronic stress Morris water maze hole-board test anxiolytic properties

TLDR Progesterone helps protect against stress-related memory and behavior issues in rats.

The study investigated the role of progesterone (PROG) in regulating stress-induced changes in corticosterone (CORT) levels, spatial memory, and exploratory behavior in adult male Wistar rats. The rats were castrated and implanted with either PROG or a vehicle, then subjected to chronic stress through crowding or ultrasonic noise for 10 days. High-performance liquid chromatography (HPLC) was used to measure PROG and CORT levels in urine. The results showed that PROG implants inhibited the stress-induced increase in CORT, prevented spatial memory impairment in the Morris water maze, and eliminated the increase in exploratory activity in the hole-board test. These findings suggested that PROG had a protective effect against the elevation of corticosterone and behavioral deficits caused by stress, potentially through its anxiolytic mechanisms.

View this study on revistas.javeriana.edu.co →

Discuss this study in the Community →

Research cited in this study

2 / 2 results

research Anxiolytic Activity of Progesterone in Progesterone Receptor Knockout Mice

151 citations , December 2004 in “Neuropharmacology”

Progesterone reduces anxiety without needing progesterone receptors.

research Urinary Steroids in Women with Androgenic Alopecia

16 citations , March 2000 in “Clinical Biochemistry”

Women with hair loss had higher levels of certain hormones, suggesting a link to a condition like PCOS.

Similar Research

5 / 1000+ results

research Steroid 5α-Reductase as a Novel Therapeutic Target for Schizophrenia and Other Neuropsychiatric Disorders

72 citations , January 2011 in “Current Pharmaceutical Design”

S5αR inhibitors might help treat schizophrenia and other mental disorders but need more research.

research Early Postnatal Allopregnanolone Levels Alteration and Adult Behavioral Disruption in Rats: Implications for Drug Abuse

2 citations , December 2019 in “Neurobiology of Stress”

Changing allopregnanolone levels in baby rats affects their adult behavior and alcohol use.

Long-Term Physiological Trends And Their Drivers: Linking Hair Hormone Concentrations With Telemetry Data In GPS-Collared Serengeti Wildebeest

research Long-Term Physiological Trends And Their Drivers: Linking Hair Hormone Concentrations With Telemetry Data In GPS-Collared Serengeti Wildebeest

January 2020

Wildebeest stress and hormone levels are influenced by food availability, human presence, and reproductive cycles.

research Effects of Altering Allopregnanolone Levels During Critical Neurodevelopmental Periods on Alcohol Consumption Vulnerability

January 2018

Early NAS level changes affect alcohol consumption vulnerability.

research Sex and Estrous Cycle Influence Diazepam Effects on Anxiety and Memory: Possible Role of Progesterone

21 citations , May 2016 in “Progress in Neuro-Psychopharmacology and Biological Psychiatry”

Diazepam's effects on anxiety and memory differ between male and female rats due to hormonal influences.

Progesterone Regulates Corticosterone Elevation and Alterations in Spatial Memory and Exploratory Behavior Induced by Stress in Wistar Rats

Research cited in this study

research Anxiolytic Activity of Progesterone in Progesterone Receptor Knockout Mice

research Urinary Steroids in Women with Androgenic Alopecia

Related Community Posts Join

community Trying to understand finasteride side effects and post finasteride syndrome

community PSA: Most men who stay on Fin will see the sexual side effects go away. Stop the fear mongering

community Boys I am just a gonner. What on earth is my scalp even going through. Looks like world war 3. Pyril 3 months. Topical melitonin/progesterone/fin, dut, fin, oral min, laser trash, anus stimulation. Nothing. Donor area is decimated 😂.

community 9 month update 1st slide 2020 at my worst vs today. 2nd slide 9 months ago vs today. 3rd, wet hair. 4th, hairline. 5th, damp hair. 6th crown view. 7th, brushed back. 8 & 9, hair in high Summer humidity. 10th, no lighting.

community Hey guys I’m a Compounding Pharmacist specialized in Hair-loss who makes Topical Finasteride Foam +/- minoxidil