Solution Blow Spinning of Programmable Biofunctionalized Polymer Fibers

June 2026 in “ ACS Applied Polymer Materials ”

Jennifer A. Lee, Susan K. Kozawa, Ann M. Kulisiewicz, Terry Henderson, Ashish Tripathi, Steven M. Blum, John R. Biondo, Tahiyah Brinkley, Kristian M. Van de Voorde, Marilyn S. Lee

TLDR New polymer fibers can produce proteins and have potential uses in masks and swabs.

This study presents a novel method for creating biofunctional polymer fibers by integrating DNA-programmable cell-free protein synthesis systems into fibers using solution blow spinning. The fibers successfully produce proteins in situ, maintaining biological activity after fabrication. The research highlights the fibers' potential applications in respirator masks and sampling swabs, showcasing their versatility as a platform for user-defined biological functions. The technique offers a promising approach for developing advanced materials for portable sensing, smart textiles, and active filtration, combining complex biological functionality with customizable fiber properties.

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