Prostaglandin-Associated Periorbitopathy: Case Report and Basic Pathophysiological Reminder

Prostaglandin analogues such as latanoprost and travoprost, along with the prostamide bimatoprost, were commonly used in glaucoma treatment due to their effectiveness in lowering intraocular pressure. Known side effects included trichomegaly, increased periocular pigmentation, and adnexal hair growth. However, a rare side effect termed prostaglandin-associated periorbitopathy was identified, characterized by changes such as deepening of the upper lid sulcus, ptosis, enophthalmus, regression in dermatochalasis, and lower lid lateral orbital fat pad prolapsus. This case report highlighted this uncommon side effect in three glaucoma patients treated with bimatoprost and travoprost, emphasizing the need to consider these potential changes in clinical practice.