Increased Levels of Prostaglandin-Like Material in Canine Blood During Arterial Hypotension Produced by Hydralazine, Dihydralazine, and Minoxidil

    December 1979 in “ Naunyn-schmiedebergs Archives of Pharmacology ”
    Guenther Haeusler, Marcel Gerold
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    TLDR These drugs raise prostaglandin-like material in dog blood, possibly causing blood vessel widening.
    The study found that hydralazine, dihydralazine, and minoxidil increased the levels of prostaglandin-like material in the blood of dogs during arterial hypotension. The increase in prostaglandin-like material was specific to these drugs and not observed with other hypotensive agents. The study suggests that prostaglandins may be responsible for the vasodilation produced by these drugs.
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