Effect of Platelet-Rich Plasma on Dermal Skin Flap Survival: An Experimental Study in Rats

The study examined the impact of leukocyte-rich platelet-rich plasma (L-PRP) on the survival of dorsal skin flaps in 16 female Wistar rats. The treatment group receiving L-PRP showed significantly improved flap viability and reduced necrosis compared to the control group, with mean necrosis at 0.59 versus 0.82 in the control. No severe necrosis was observed in the L-PRP group. The study concluded that L-PRP enhances skin flap viability without adverse effects, indicating its potential for improving skin flap survival. However, the findings are preliminary due to the small sample size and other limitations.