Effect of Platelet-Rich Plasma in the Treatment of Acne Scars: Systematic Review and Meta-Analysis

August 2020 in “ Universidad Peruana de Ciencias Aplicadas (UPC) ”

Dyurliza Lizbeth Hermenegildo Ferro, Zully Faby Elvita Sánchez Perales

platelet-rich plasma atrophic acne scars Goodman and Barón scale PRP

TLDR Platelet-rich plasma (PRP) effectively improves acne scars.

This systematic review and meta-analysis evaluated the efficacy and safety of platelet-rich plasma (PRP) as an adjunctive treatment for atrophic acne scars. The study included 14 controlled clinical trials with a total of 429 participants. The results demonstrated that PRP was superior as an adjuvant therapy, showing significant clinical improvement in studies using quartile scales (RR=1.79; 95% CI 1.39–2.31) and the qualitative Goodman and Barón scale (RR=4.34; 95% CI 1.60–11.76). These findings suggested that PRP could be an effective treatment option for improving acne scars.

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Research cited in this study

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research Comment on 'Platelet-Rich Plasma and Its Utility in the Treatment of Acne Scars: A Systematic Review'

4 citations , September 2019 in “Journal of The American Academy of Dermatology”

Platelet-rich plasma combined with other treatments improves acne scars better than those treatments alone.

research The Efficacy of Platelet-Rich Plasma in Hair Restoration and Facial Aesthetics: A Systematic Review and Meta-Analysis

31 citations , January 2019 in “Journal of Cutaneous Medicine and Surgery”

Platelet-Rich Plasma (PRP) therapy can promote hair growth and improve facial aesthetics, including reducing acne scars and facial burns, and it works best with three initial monthly injections.

research Is Skin Microneedling a Good Alternative Method for Various Skin Defects Removal

23 citations , September 2018 in “Dermatologic Therapy”

Microneedling is a safe and effective way to improve various skin conditions with minimal side effects.

research A Review of Platelet-Rich Plasma: History, Biology, Mechanism of Action, and Classification

348 citations , July 2017 in “Skin appendage disorders”

Platelet-rich plasma shows promise for skin and hair treatments but needs more research and standardization.

research Microneedling: Current Status and Systematic Literature Review

92 citations , June 2017 in “Journal of Plastic Reconstructive and Aesthetic Surgery”

Microneedling is a safe and effective treatment for various skin conditions, often preferred for its fewer side effects and shorter recovery time.

Combined Autologous Platelet-Rich Plasma with Microneedling Versus Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-Face Study

research Combined Autologous Platelet-Rich Plasma with Microneedling Versus Microneedling with Distilled Water in the Treatment of Atrophic Acne Scars: A Concurrent Split-Face Study

106 citations , January 2016 in “Journal of Cosmetic Dermatology”

Using platelet-rich plasma with microneedling works better for acne scars than microneedling with water.

research Systematic Review of the Use of Platelet-Rich Plasma in Aesthetic Dermatology

113 citations , July 2015 in “Journal of Cosmetic Dermatology”

Platelet-rich plasma may help with hair growth and skin quality but more research is needed to confirm its effectiveness.

research Microneedle Applications in Improving Skin Appearance

131 citations , May 2015 in “Experimental Dermatology”

Microneedles help improve skin appearance and deliver skin treatments effectively, but safety concerns need more research and regulation.

research Platelet-Rich Plasma: Applications in Dermatology

22 citations , January 2015 in “Actas dermo-sifiliográficas/Actas dermo-sifiliográficas”

Platelet-rich plasma might help with skin aging, ulcers, and hair loss, but more research is needed to prove its effectiveness and safety.

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