Platelet-Rich Plasma for the Treatment of Tissue Infection: Preparation and Clinical Evaluation

    February 2019 in “ Tissue Engineering Part B Reviews
    Wenhai Zhang, Yue Guo, Mitchell Kuss, Wen Shi, Amy L. Aldrich, Jason Untrauer, Tammy Kielian, Bin Duan
    TLDR Platelet-rich plasma can effectively treat and prevent tissue infections.
    The document reviewed the use of platelet-rich plasma (PRP) as a treatment for tissue infections, highlighting its potential as an adjunct therapy for surgical wounds and tissue injuries. PRP, derived from whole blood, releases antimicrobial proteins, cytokines, and growth factors that aid in pathogen elimination, necrotic tissue resolution, and wound healing. It was noted for its synergistic effect with antibiotics, particularly against antibiotic-resistant bacteria. The review emphasized PRP's overlooked antibacterial properties and summarized preclinical and clinical evidence supporting its use in preventing and treating wound and bone infections, suggesting its advantages due to its biocompatibility and healing-promoting properties.
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