Platelet-Rich Plasma in Cosmetic Surgery

The 2013 document reviews the use of platelet-rich plasma (PRP) in cosmetic surgery, emphasizing its role in enhancing wound healing and its potential in esthetic procedures like hair restoration and soft tissue augmentation. PRP, which is plasma with higher levels of platelets and growth factors, is believed to aid in tissue regeneration through the release of growth factors such as PDGF, TGF-ß, and VEGF. These factors contribute to cell differentiation, proliferation, collagen synthesis, and angiogenesis. The document highlights PRP's clinical applications in skin rejuvenation, recovery time reduction in procedures like CO₂ laser resurfacing, and improved soft tissue healing. It also notes PRP's promise in hair restoration, where it may stimulate hair regrowth and increase hair thickness. PRP is prepared by centrifugation of whole blood and activation of platelets. Despite the potential benefits, the document cautions about the variability in clinical outcomes and suggests that future positive study results could establish PRP as a standard in cosmetic surgery. Two FDA-approved systems for PRP preparation mentioned are Selphyl and RegenKit.