Addressing Knee Osteoarthritis Pathology Through Platelet-Rich Plasma Treatment: A Comprehensive Review

This comprehensive review evaluates platelet-rich plasma (PRP) as a treatment for knee osteoarthritis (KOA), affecting over 300 million people globally. PRP, derived from blood platelets, releases growth factors that aid in cartilage repair and reduce inflammation, showing promise in improving joint health and delaying invasive procedures. The review analyzed 105 studies, finding PRP more effective than hyaluronic acid or placebo, with benefits lasting up to 12 months. However, inconsistent PRP preparation methods and a lack of long-term data present challenges. Future research should focus on standardizing PRP protocols and understanding its molecular mechanisms to enhance patient outcomes and integrate PRP into KOA management effectively.