Clinical and Trichoscopic Analysis of PRP Versus GFC for Male and Female Pattern Hair Loss

June 2025 in “ Dermatologic Surgery ”

Suruchi Garg, Aparna Thirumalaiswamy

platelet-rich plasma growth factor concentrate male pattern hair loss female pattern hair loss Global Aesthetic Improvement Scale bulbar enlargement erythema angiogenesis PRP GFC GAIS

TLDR GFC improves hair quickly, while PRP offers longer-lasting benefits; using both sequentially is recommended.

This study compared the efficacy and safety of platelet-rich plasma (PRP) and growth factor concentrate (GFC) in treating male and female pattern hair loss. It involved 42 patients, with 25 receiving PRP and 17 receiving GFC, each undergoing three treatment sessions. Results indicated that GFC led to better outcomes in total hair count, shaft diameter, and Global Aesthetic Improvement Scale (GAIS) scores, with significant improvements after the second session. GFC also showed more bulbar enlargement, while PRP resulted in more erythema and angiogenesis. At 6 months, PRP demonstrated better hair diameter and GAIS scores, suggesting a more sustained effect. The study concludes that both treatments improve hair parameters, with GFC providing quick improvement and PRP offering long-term benefits, recommending sequential treatments for sustainable results.

View this study on journals.lww.com →

Discuss this study in the Community →

Research cited in this study

5 / 5 results

Comparing Single-Spin Versus Double-Spin Platelet-Rich Plasma Centrifugation Methods on Thrombocyte Count and Clinical Improvement of Androgenetic Alopecia: A Preliminary, Randomized, Double-Blind Clinical Trial

research Comparing Single-Spin Versus Double-Spin Platelet-Rich Plasma Centrifugation Methods on Thrombocyte Count and Clinical Improvement of Androgenetic Alopecia: A Preliminary, Randomized, Double-Blind Clinical Trial

December 2023 in “PubMed”

Both single-spin and double-spin PRP methods effectively treat hair loss, with single-spin slightly increasing platelet count more.

research Growth Factor Concentrate Therapy for Management of Hair Loss: A Prospective, Real-World Study

December 2022 in “International Journal of Research in Dermatology”

Growth factor concentrate therapy helps manage hair loss.

research Platelet-Rich Plasma in Interventional Dermatology and Trichology: How Far Have We Come?

2 citations , June 2021 in “Cosmoderma”

Platelet-rich plasma (PRP) shows promise in skin and hair treatments but results vary with preparation methods.

research Platelet-Rich Plasma—An 'Elixir' for Treatment of Alopecia: Personal Experience on 117 Patients with Review of Literature

31 citations , July 2017 in “Stem cell investigation”

Platelet-rich plasma (PRP) is a simple, cost-effective treatment that promotes hair growth and reduces hair loss, with high patient satisfaction.

research Platelet-Rich Plasma as a Potential Treatment for Noncicatricial Alopecias

58 citations , January 2015 in “International Journal of Trichology”

Platelet-rich plasma, which carries growth factors, could be a promising treatment for non-scarring hair loss, promoting hair growth and density with no major side effects.