Effect of Platelet-Rich Plasma on Hair Follicle Growth in C57BL/6 Mice

February 2026 in “ Aesthetic Plastic Surgery ”

Guangyu Mao, Huijuan Mao, Xiuchun Wang, Xing Wang

platelet-rich plasma PRP hair follicle growth Wnt10b hair matrix inner hair root sheath cells alopecia

TLDR Platelet-rich plasma (PRP) speeds up hair growth in mice.

The study investigated the effects of platelet-rich plasma (PRP) on hair follicle growth in 20 female C57BL/6 mice, divided into experimental and control groups. The experimental group received subcutaneous injections of PRP, while the control group received saline. Results showed that the experimental group experienced faster hair growth and higher expression of Wnt10b, a protein associated with hair follicle proliferation. This suggests that PRP promotes the proliferation of hair matrix and inner hair root sheath cells, accelerating the hair follicle cycle, making it a promising treatment for alopecia.

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Research cited in this study

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research Platelet-Rich Plasma for Treating Androgenic Alopecia: A Systematic Review

27 citations , June 2019 in “Aesthetic Plastic Surgery”

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research Treatment of Male Pattern Alopecia with Platelet-Rich Plasma: A Double-Blind Controlled Study with Analysis of Platelet Number and Growth Factor Levels

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research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

3 citations , May 2017 in “Dermatologic Surgery”

PRP may help treat female hair loss, but more research needed.

The Effect of Autologous Activated Platelet-Rich Plasma Injection on Female Pattern Hair Loss: A Randomized Placebo-Controlled Study

research The Effect of Autologous Activated Platelet-Rich Plasma Injection on Female Pattern Hair Loss: A Randomized Placebo-Controlled Study

52 citations , May 2017 in “Journal of Cosmetic Dermatology”

PRP injections improve hair density and thickness in women with hair loss.

research The Effect of Plasma Rich in Growth Factors on Pattern Hair Loss: A Pilot Study

70 citations , February 2017 in “Dermatologic Surgery”

Treatment with plasma rich in growth factors improved hair density and thickness for hair loss patients.

research Double-Blind, Placebo-Controlled Pilot Study on the Use of Platelet-Rich Plasma in Women With Female Androgenetic Alopecia

87 citations , September 2016 in “Dermatologic Surgery”

PRP shows potential for treating female hair loss, but more research needed.

research Efficacy of Platelet-Rich Plasma in the Treatment of Androgenetic (Male-Patterned) Alopecia: A Pilot Randomized Controlled Trial

61 citations , September 2016 in “Journal of Cosmetic and Laser Therapy”

Platelet-rich plasma (PRP) was found not effective in treating male-patterned hair loss.

research Meta-Analysis of Efficacy of Platelet-Rich Plasma Therapy for Androgenetic Alopecia

57 citations , May 2016 in “Journal of Dermatological Treatment”

PRP therapy may effectively treat hair loss, but more research needed.

research Modulating Hair Follicle Size with Wnt10b/DKK1 During Hair Regeneration

53 citations , April 2014 in “Experimental Dermatology”

Wnt10b makes hair follicles bigger, but DKK1 can reverse this effect.

Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

research Adverse Side Effects of 5α-Reductase Inhibitors Therapy: Persistent Diminished Libido, Erectile Dysfunction, and Depression in a Subset of Patients

223 citations , December 2010 in “The Journal of Sexual Medicine”

Some patients taking finasteride or dutasteride may have ongoing sexual problems and depression even after stopping the medication.

research The Role of Platelet Plasma Growth Factors in Male Pattern Baldness Surgery

251 citations , October 2006 in “Plastic and reconstructive surgery/PSEF CD journals”

Using platelet plasma growth factors in baldness surgery can increase the number of hair follicles.

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