Pyridoxine Regulates Hair Follicle Development via the PI3K/Akt, Wnt, and Notch Signalling Pathways in Rex Rabbits

    October 2021 in “ Animal nutrition ”
    Gongyan Liu, Guangcun Cheng, Zhang Yongcui, Shuxia Gao, Haitao Sun, Liya Bai, Shu Li, Yanli Zhu, Chunyang Wang, Fuchang Li
    TLDR Vitamin B6 helps increase hair growth and density in rabbits by affecting certain cell signaling pathways.
    A study conducted on 200 rex rabbits found that pyridoxine, also known as vitamin B6, significantly increased hair follicle density and promoted hair growth. The rabbits were divided into 5 groups and fed diets supplemented with 0, 5, 10, 20, or 40 mg/kg of pyridoxine. The results showed that pyridoxine increased total follicle density, secondary follicle density, and the secondary-to-primary ratio. It also promoted the growth of hair stems and increased the growth length of hair follicles. Pyridoxine affected the gene expression of components of the PI3K/Akt, Wnt, and Notch signalling pathways, which are crucial for hair growth. However, it had no effect on the gene expression of BMP2, BMP4, or TGF-β1, components of the BMP signalling pathway. The study concluded that pyridoxine could potentially be used to promote hair growth and delay hair follicle degeneration.
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