Radioprotective Effects of Soy Isoflavones on Normal Lung Tissue Could Translate to Improved Radiation Therapy Outcomes for Lung Cancer

    October 2012 in “ International journal of radiation oncology, biology, physics ”
    Gilda G. Hillman, Vinita Singh‐Gupta, David J. Hoogstra, Christopher K. Yunker, Lisa M. Abernathy, J Rakowski, Fazlul H. Sarkar, André Konski, Fulvio Lonardo, Michael C. Joiner
    TLDR Soy isoflavones can protect lung tissue from damage during radiation therapy for lung cancer.
    The study investigated the radioprotective effects of soy isoflavones on normal lung tissue in a mouse model subjected to radiation therapy. Mice pre-treated with soy isoflavones showed significantly reduced radiation-induced hair loss and maintained normal breathing rates compared to those only exposed to radiation. Histological analysis revealed that soy isoflavones mitigated radiation-induced inflammation and damage in lung tissues, preserving normal lung structures. These findings suggested that soy isoflavones could protect normal lung tissue from radiation injury, potentially improving the outcomes of radiation therapy for lung cancer.
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