A Rare Case of Adolescent Girl with Beard-PCOS with a Difference: HAIR-AN Syndrome

January 2022 in “ Dubai diabetes and endocrinology journal/Dubai diabetes & endocrinology journal ”

Payal S. Kubsad, Vani Hebbal Nagarajappa, Dhanya Mohan

HAIR-AN syndrome PCOS hyperandrogenism insulin resistance acanthosis nigricans beard growth irregular menstrual cycles hyperpigmentation elevated insulin elevated testosterone metformin spironolactone oral contraceptives polycystic ovary syndrome irregular periods skin darkening birth control pills

TLDR A 16-year-old girl with HAIR-AN syndrome was treated with lifestyle changes and medications to manage her condition.

The document discusses a rare case of a 16-year-old girl diagnosed with HAIR-AN syndrome, a subtype of PCOS marked by hyperandrogenism, insulin resistance, and acanthosis nigricans. She presented with atypical symptoms such as beard growth, irregular menstrual cycles, and hyperpigmentation. Clinical evaluations showed elevated insulin and testosterone levels. Treatment with lifestyle changes, metformin, spironolactone, and oral contraceptives led to symptom improvement and reduced acanthosis. The case emphasizes the need for early diagnosis and a multidisciplinary approach to manage HAIR-AN syndrome effectively.

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research Hyperandrogenism-Insulin Resistance-Acanthosis Nigricans Syndrome

7 citations , January 2015 in “Case reports in endocrinology”

The document concludes that HAIR-AN syndrome should be considered when a patient shows severe hyperandrogenism and insulin resistance after excluding tumors.