A Rare Pediatric Case of Loose Anagen Hair Syndrome

January 2026

S. Manoj Gowda, Manoj Pavan, Nourin Abdul Azeez, Neha Taneja, Somesh Gupta

loose anagen hair syndrome LAS keratin hair anchorage hair shaft root sheath trichoscopic findings histopathological findings topical minoxidil Rogaine

TLDR Loose anagen hair syndrome in children may improve with age, but treatment results vary.

This article discusses a rare pediatric case of loose anagen hair syndrome (LAS) in a 13-year-old girl, characterized by excessive hair shedding and sparse, unruly hair. LAS is a disorder of hair anchorage due to mutations affecting keratin, leading to defective adhesion between the hair shaft and root sheath. The diagnosis was confirmed through clinical, trichoscopic, and histopathological findings. Despite treatment with topical minoxidil for 6 months, no significant improvement was observed. LAS often improves spontaneously with age, but responses to treatment can vary, highlighting the importance of early recognition and realistic counseling for patients and caregivers.

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