The Reason for the Palace

January 2008 in “ Catalunya música: Revista musical catalana ”

Pere Artís

premature hair graying tyrosinase-related protein-2 TRP-2 trigeminal nerve masticatory function maxillary first molars tooth loss gray hair nerve input molar loss

TLDR Tooth loss can cause premature gray hair due to less chewing.

This study investigated the effect of reduced mastication on premature hair graying by extracting maxillary first molars from young mice and observing them for 3 months. The results showed that gray hair appeared in the interbrow region of the tooth extraction group but not in the control group. Additionally, the expression of tyrosinase-related protein-2 (TRP-2) mRNA was lower in the interbrow tissues of mice without maxillary molars. The findings suggested that tooth loss leads to interbrow gray hair growth, possibly due to weakened trigeminal nerve input, indicating that reduced mastication causes premature graying. Prompt prosthetic treatment after molar loss was recommended.

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Research cited in this study

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research Reversal of Premature Hair Graying Treated with a Topical Formulation Containing α-Melanocyte-Stimulating Hormone Agonist (Greyverse Solution 2%)

1 citations , November 2022 in “International journal of trichology”

A woman's premature gray hair turned mostly black again after using Greyverse solution and hair supplements for 5 months.

research The Psychology of Gray Hair

2 citations , March 2020 in “Developmental cell”

Stress can cause hair to turn gray by depleting pigment-producing cells through the release of a stress hormone.

research Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss

688 citations , June 2007 in “Cell Stem Cell”

Removing the ATR gene in adult mice causes rapid aging and stem cell loss.

The Reason for the Palace

Research cited in this study

research Reversal of Premature Hair Graying Treated with a Topical Formulation Containing α-Melanocyte-Stimulating Hormone Agonist (Greyverse Solution 2%)

research The Psychology of Gray Hair

research Hyperactivation of Sympathetic Nerves Drives Depletion of Melanocyte Stem Cells

research A Review of the Etiologies, Clinical Characteristics, and Treatment of Canities

research Association of Premature Hair Graying with Family History, Smoking, and Obesity: A Cross-Sectional Study

research Deletion of the Developmentally Essential Gene ATR in Adult Mice Leads to Age-Related Phenotypes and Stem Cell Loss