Recent progress in PLGA-based microneedle-mediated transdermal drug and vaccine delivery

The document reviewed the recent advances in PLGA-based microneedles (MNs) for transdermal delivery of drugs, vitamins, proteins, and vaccines. It highlighted the ability of polymeric MN arrays to penetrate the skin's stratum corneum with minimal invasiveness, allowing for targeted intradermal delivery. PLGA, a nontoxic FDA-approved copolymer, was noted for its biocompatibility and biodegradability, making it a promising material for MNs. The study discussed both PLGA nanoparticle-based and matrix-based MNs, their applications, and the potential they held for improving transdermal delivery. Additionally, the paper addressed the prospects and challenges associated with PLGA-based MNs.