Red LED Photobiomodulation Enhances Metabolic Activity in Cultured Human Pericytes

    January 2026 in “ Journal of Hard Tissue Biology ”
    Yuki Ito, Yoshihiko Sugita, Kei Kamiya, Yoshitaka Nagaya, Tomofumi Hattori, Masanori Nagasawa, Ryoko Kawai, Ms. Waka Yoshida, Katsutoshi Kubo, Hatsuhiko Maeda
    TLDR Red LED light boosts cell activity and growth, aiding wound healing and blood vessel repair.
    Red LED photobiomodulation (PBM) at 655 nm significantly enhances metabolic activity and proliferation in cultured human pericytes, as demonstrated by increased cell proliferation and upregulation of angiogenesis-related markers (Ang-1, CD146, PDGFR-β, VEGF-A) at 3, 6, and 24 hours post-irradiation. The study found no temperature elevation during LED exposure, indicating a safe application. These findings suggest that red LED PBM could be a promising non-invasive strategy for promoting wound healing and vascular regeneration by activating pericytes.
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