Referee Report: Hair Greying in Castrated Mice

The study on hair greying in castrated mice found that a single session of hair plucking induced greying in about 33% of castrated mice, but not in sham-operated ones, with the greying persisting for over 100 days. This suggested that androgen loss might accelerate hair greying, implying that decreased androgen secretion with age could contribute to human hair greying. The study proposed a new mouse model for hair greying without genetic engineering, though it noted limitations such as the need for artificial induction and partial greying. Further research was needed to understand the mechanism of androgen-related depigmentation.