September 2022 in “F1000Research” Removing hair from mice without reproductive glands led to grey hair, possibly helping to understand greying in aging.
12 citations
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October 1988 in “Clinics in dermatology” The mouse model could be useful for baldness research and testing treatments like testosterone, cyproterone acetate, and minoxidil.
38 citations
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July 1989 in “Archives of dermatological research” Testosterone causes hair loss in AGA mice, which are good for testing baldness treatments, and both minoxidil and cyproterone acetate can prevent this hair loss.
July 2026 in “bioRxiv (Cold Spring Harbor Laboratory)” The study investigates sex differences in hair cycling and adhesive material-induced hair regeneration in male and female C3H/He mice. It was found that males entered the second and third anagen phases earlier than females, suggesting longer telogen phases in females. However, females showed earlier localized hair regrowth after the application and removal of a cyanoacrylate adhesive material. Ovariectomy led to a widespread telogen-to-anagen transition, complicating the isolation of ovarian hormone effects. RNA sequencing revealed sex-dependent baseline expression profiles related to inflammation and tissue repair. Clodronate liposome treatment delayed hair growth and wound healing in males but had less impact on females, indicating a more macrophage-dependent regenerative response in males. These findings highlight distinct sex differences in physiological hair cycling and regenerative responses.
June 2025 in “International Journal of Applied Pharmaceutics” A testosterone-induced hair loss model in mice was successfully created for future research and treatment testing.
