Regenerative Medicine for Hair Health: From Principles to Practice (Part II)

January 2026 in “ Journal of the American Academy of Dermatology ”

Saranya P. Wyles, Sydney L. Proffer, Larissa Pastore, Murad Alam, Marc Avram, Ronda S. Farah, Neil S Sadick, Maria Hordinsky

regenerative medicine hair growth follicular restoration WNT signaling pathway BMP signaling pathway SHH signaling pathway mesenchymal stem cells platelet-rich plasma exosomes alopecia PRP

TLDR Regenerative therapies show promise for hair growth but need standardized protocols and safety guidelines.

The document discusses the potential of regenerative technologies for hair growth and follicular restoration, focusing on key signaling pathways like WNT, BMP, and SHH. It explores various regenerative modalities, including mesenchymal stem cells, platelet-rich plasma, and exosomes from different sources, which show promise for treating various forms of alopecia. However, these therapies face challenges such as variability in protocols, lack of standardization, and the need for long-term safety and regulatory guidance. The article aims to educate clinicians and trainees by defining terminology, summarizing scientific principles, and highlighting current research directions, emphasizing the importance of scientific, ethical, and regulatory rigor in integrating future advances.

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Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

community Compressed part of research of theory of androgenic/anabolitic balance. AGA h-responders analytic. Theory of physio-metabolitic method of anti AGA treatment

in Research 865 upvotes 1 year ago

The treatment for androgenetic alopecia involves using finasteride and minoxidil with intense exercise and cold exposure to boost metabolism and reduce androgenic effects, potentially leading to hair regrowth. This approach may activate biological pathways for improved hair and overall health.

community New Treatments, and a Huge Group Buy with Lots of Research

in Research/Science 109 upvotes 2 years ago

A user is organizing a group buy for various compounds aimed at reversing hair loss and gray hair, and improving brain health and fat loss. The user has developed a treatment plan based on extensive research and is inviting others to participate, with the option to choose only the compounds they need.

community We should actually be hopeful for these recent new developments

in Research/Science 110 upvotes 9 months ago

AI advancements, like AlphaFold, are speeding up drug discovery for hair loss, promising more effective treatments. Current options like minoxidil and finasteride have limitations, but new developments could improve solutions in 5-10 years.

community New and Interesting HairLoss Studies/Papers/Reviews

in Treatment 40 upvotes 6 years ago

Hair loss treatments discussed include Dutasteride with Ketoconazole, tissue engineering strategies, and androgenetic alopecia therapies. Massage doubles follicular retention, improving treatment effectiveness.

community Verteporfin and Microneedling

in Treatments 1 year ago

Clinical studies by Dr. Barghouthi and Dr. Bloxham indicate that Verteporfin, when used with FUE and FUT hair transplantation methods, shows promise in hair follicle regeneration and minimal scarring due to its ability to inhibit Yes-associated protein (YAP). Microneedling at depths of 3-3.5mm, combined with Verteporfin, could potentially reactivate dormant follicles, although the optimal dosage and application method are still under investigation. Concerns remain about the DHT sensitivity of regenerated follicles, highlighting the need for further research to optimize trauma levels and Verteporfin concentrations to achieve effective and scar-free hair regeneration.

community HairClone developing cell replacement treatments for Hair Loss

6 upvotes 7 years ago

HairClone is developing cell replacement treatments to rejuvenate and generate hair follicles, and has launched a crowdfunding campaign. A user expressed skepticism about the need for crowdfunding.

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research Proceedings of the Ninth World Congress for Hair Research 2015

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