Research progress and strategies for the biosynthesis of keratinocyte growth factor-2 (KGF-2) in <i>Arabidopsis thaliana</i>

The document reviews the potential of using Arabidopsis thaliana as a plant bioreactor for the biosynthesis of keratinocyte growth factor-2 (KGF-2), which is beneficial for hair growth, wound healing, and scar repair. It highlights the advantages of plant-based systems, such as safety, scalability, and cost-effectiveness, and suggests that fusing KGF-2 with transdermal peptides could enhance its delivery and stability. The study explores the use of A. thaliana to express a fusion protein, TDP1-KGF-2, to improve transdermal absorption and reduce production costs, offering a promising approach for developing natural hair growth products. The research emphasizes the potential of plant bioreactors in creating sustainable and effective therapeutic products for medical and cosmetic applications.