Restoring Neuropeptide Y Levels In The Hypothalamus Ameliorates Premature Aging Phenotype In Mice

    February 2025 in “ GeroScience ”
    Marisa Ferreira‐Marques, Sara Carmo‐Silva, Joana Pereira, Mariana Botelho, Clévio Nóbrega, Carlos López-Otı́n, Luís Pereira de Almeida, Célia A. Aveleira, Cláudia Cavadas
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    TLDR Increasing neuropeptide Y in the brain can slow aging signs in mice.
    The study demonstrates that restoring neuropeptide Y (NPY) levels in the hypothalamus of mice can delay features associated with aging, such as lipodystrophy, alopecia, and memory decline. These findings indicate that strategies aimed at maintaining hypothalamic NPY levels could be significant in combating the progression of aging and related deteriorations.
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