Rickets in Association with Skin Diseases and Conditions: A Review with Emphasis on Screening and Prevention

July 2020 in “ Photodermatology Photoimmunology & Photomedicine ”

N. Litaiem, I. Chabchoub, T. Bacha, M. Slouma, Faten Zéglaoui, Amor Khachemoune

rickets skin diseases vitamin D synthesis ichthyosis alopecia psoriasis vitamin D-dependent rickets hypocalcemic vitamin D-dependent rickets type 2 hypophosphatemic rickets cutaneous skeletal hypophosphatemia syndrome vitamin D

The review highlighted the association between rickets and various skin diseases, emphasizing the role of the skin in vitamin D synthesis. It identified conditions such as ichthyosis, alopecia, and psoriasis as being linked to rickets, with ichthyosis being particularly notable due to its impact on vitamin D synthesis. The study categorized rickets into three types: vitamin D-dependent rickets, hypocalcemic vitamin D-dependent rickets type 2, and hypophosphatemic rickets, with a focus on the newly described cutaneous skeletal hypophosphatemia syndrome. The review stressed the importance of early diagnosis by dermatologists to prevent growth retardation and skeletal deformities in affected individuals.

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Three new gene mutations cause rickets and hair loss, treatable with high calcium and calcidol, but hair regrowth is rare.

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A boy's hair loss and bone issues improved with specific vitamin D treatment and calcium.

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