Long-Term Efficacy, Complete Scalp Hair Regrowth and Normal Body Hair/Nails in Adolescents With Severe Alopecia Areata Receiving Ritlecitinib Up to 3 Years in the Allegro Clinical Trials

    July 2026 in “ Journal of the American Academy of Dermatology ”
    Lidia Rudnicka, J. Mazereeuw‐Hautier, Ilka Arun Netravali, Kazutoshi Harada, Cheng Zhou, Katya Harfmann, Dalia Wajsbrot, Rahmat Adejumo, Alanna Chaudhry, Robert Wolk, Helen Tran
    TLDR Ritlecitinib helps adolescents with severe alopecia areata regrow scalp hair and normalize body hair and nails.
    The ALLEGRO clinical trials investigated the long-term efficacy of ritlecitinib in adolescents with severe alopecia areata (AA) over a period of up to 3 years. The study demonstrated that ritlecitinib led to complete scalp hair regrowth and normalization of body hair and nails in the participants. This suggests that ritlecitinib could be a promising treatment option for adolescents suffering from severe AA, providing sustained benefits over an extended period. The study's findings are significant for the potential management of alopecia areata in younger populations.
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