RNA Modifications: Molecular Orchestrators of Wound Healing

This review explores the significant role of RNA modifications, particularly N6-methyladenosine (m6A), in wound healing across various tissue types, including skin, bone, and corneal injuries. It highlights how these modifications regulate key processes such as inflammation, cell proliferation, and angiogenesis, with specific enzymes like METTL3 and FTO playing crucial roles. The review suggests that RNA modifications could serve as therapeutic targets, proposing interventions like topical hydrogels and exosome-based therapies. However, it emphasizes the need for clinical trials and biomarker strategies to translate preclinical findings into patient care, especially for managing diabetic wounds and burn injuries. Despite the potential, challenges remain in developing targeted delivery systems and understanding cell-type-specific modification dynamics.