Role of ASLNC168501 in Regulating Hair Follicle Stem Cell Activity via the AR/miR-128-3p/IGF-1 Pathway

    January 2026 in “ Figshare ”
    Xuewen Chen, Jingxiu Chai, Xuan Wang, Leimeng Gan, Qing Zhang, Hao Luo, Ling Wu, Yuchong Chen
    TLDR ASLNC168501 may help restore hair growth in androgenetic alopecia by improving hair follicle stem cell function.
    This study investigates the dysfunction of hair follicle stem cells (HFSCs) in androgenetic alopecia (AGA) and identifies the AR/miR-128-3p/IGF-1 pathway as a key factor. It was found that IGF-1 expression is significantly reduced in AGA patients, leading to impaired HFSC activity. The study reveals that the endogenous RNA ASLNC168501 can sequester miR-128-3p, restoring IGF-1 expression and supporting HFSC function. Overexpression of ASLNC168501 in dermal papilla cells enhanced HFSC self-renewal and reversed hair follicle atrophy in AGA mice. These findings suggest that ASLNC168501 could be a promising therapeutic target for hair regeneration in AGA.
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