The Role of Propionibacterium Acnes in Acne Vulgaris

    January 2019 in “ Advances in Environmental Biology ”
    Neama Ahmad Al-Nabati, Ahmed M. Al-Hejin, Nouf Talal Mleeh, Noor M. Bataweel, Mohamed Abu-Zaid, Samah O. Noor, Maged Mostafa Mahmoud, Azhar Najjar, Mohamed Morsi M. Ahmed, B Drno, A Byrd, Y Belkaid, J Segre, H Williams, R Dellavalle, S Garner, H Omer, A Mcdowell, O Alexeyev, H Nasri, M Bahmani, N Shahinfard, A Nafchi, S Saberianpour, M Kopaei, A O'neill, R Gallo, K Bhate, H Williams, O Schaefer, O Findlay, R Park, L Cordain, S Lindeberg, M Hurtado, K Hill, S Eaton, J Brand-Miller, T Schfer, A Nienhaus, D Vieluf, J Berger, J Ring, S Taylor, F Cook-Bolden, Z Rahman, D Strachan, H Yahya, B Adityan, D Thappa, B Wei, Y Pang, H Zhu, L Qu, T Xiao, H Wei, H Chen, C He, A Perry, P Lambert, M Capoor, F Ruzicka, T Machackova, R Jancalek, M Smrcka, J Schmitz, F, I Ishige, Y Eishi, T Takemura, I Kobayashi, K Nakata, I Tanaka, S Nagaoka, K Iwai, H Lomholt, M Kilian, H Kwon, D Suh, B Drno, S Pcastaings, S Corvec, S Veraldi, A Khammari, C Roques, K Nakase, N Hayashi, Y Akiyama, S Aoki, N Noguchi, C Beylot, N Auffret, F Poli, J Claudel, M Leccia, P Del Giudice, B Dreno, T Coenye, E Peeters, H Nelis
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    TLDR Propionibacterium acnes contributes to acne and antibiotic resistance, needing new treatments.
    The document reviewed the role of Propionibacterium acnes in acne vulgaris, noting its involvement in the disease's pathogenesis through mechanisms like increased sebum production and inflammatory responses. It highlighted the rise of antibiotic-resistant strains, particularly to erythromycin and clindamycin, due to long-term antibiotic use. The study, involving 33 patients, found a correlation between high acne levels and antibiotic-resistant strains. It emphasized the need for new treatments that reduce bacterial inflammation without causing resistance and maintain the natural skin barrier. Despite its association with acne, the exact relationship between P. acnes and acne vulgaris remained debated.
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