The Current and Emerging Role of Statins in the Treatment of Polycystic Ovary Syndrome: The Evidence to Date

    January 2024 in “ Medicina ”
    Tea Shehu Kolnikaj, Rok Herman, Andrej Janež, Mojca Jensterle
    TLDR Statins may help treat PCOS by lowering androgen levels and improving cholesterol.
    The review examines the potential role of statins in treating Polycystic Ovary Syndrome (PCOS), focusing on their ability to improve lipid profiles, reduce androgen levels, and address inflammation. Statins, such as atorvastatin and simvastatin, have shown promise in lowering testosterone and other androgens, which are often elevated in PCOS. However, concerns about their impact on insulin sensitivity and potential side effects, such as muscle-related symptoms and increased risk of new-onset diabetes, necessitate further research. The evidence, while promising, is still evolving, and more well-designed studies are needed to establish clear guidelines for the use of statins in PCOS management.
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